Major League Baseball will open its 2027 regular season on Wednesday, March 24, the earliest Opening Day in league history, with a single game to be broadcast exclusively on Netflix featuring two teams yet to be determined [1, 2, 3]. The traditional multi-game Opening Day involving most teams is scheduled for the following day, Thursday, March 25 [1, 2, 3].

The 2027 regular season will conclude on Sunday, September 26 [1, 2]. The Chicago Cubs will host the 97th All-Star Game and Home Run Derby at Wrigley Field, with the Derby on July 12 and the All-Star Game on July 13 [1, 3]. The second half of the season begins on July 15 and includes an 11-game "Rivalry Weekend" of interleague matchups through July 18 [1].

Other notable dates include the Toronto Blue Jays hosting the Los Angeles Angels on Canada Day, July 1 [1]. The Oakland Athletics will have back-to-back home series at Las Vegas Ballpark starting May 31 against the San Diego Padres and continuing June 3 versus the Cincinnati Reds [1, 2].

As of now, there are no overseas games scheduled for 2027, due to the absence of a signed labor agreement [2]. The current Collective Bargaining Agreement expires December 1, 2026, raising the risk of a work stoppage that could delay or cancel games [2, 3]. The last MLB lockout delayed the 2022 Opening Day from March 31 to April 7 [2, 3].

MLB owners publicly say the sport needs a salary cap to "level the field," while players have opposed a cap, citing limits on their earnings [3].

With the labor agreement deadline on December 1 approaching, MLB will monitor negotiations closely. The season opener on March 24 will officially launch the campaign, barring labor disruptions [1, 2, 3].